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KMID : 0364820150510030308
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Korean Journal of Microbiology
2015 Volume.51 No. 3 p.308 ~ p.311
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Peptide H reduces TNFα expression in human breast cancer MDA-MB-231 cells
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Sung Dae-Il
Park Jam-Eon
Kang Choong-Kyung
Kim Han-Bok
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Abstract
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Chungkookjang (fermented soybeans) contains diverse peptides. Human breast cancer MDA-MB-231 cells were treated with peptide H derived from Chungkookjang, and TNFα expression in the cells was conspicuously repressed, suggesting peptide H’s regulation of IL6 since IL6 is induced by TNFα. The structure of peptide H was different from those of glucocorticoid and dexamethasone, suggesting different mechanisms of TNFα expression suppression. Peptide H which reduces TNFα expression can be developed as drugs for cancer, rheumatoid arthritis and Crohn’s disease, after more investigation.
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KEYWORD
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breast cancer, inflammation, peptide, TNFα
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